Ageing: a universal journey we all embark on, but what if we could navigate it with deeper understanding and precision?

Ageing is a natural and inevitable process that impacts most living organisms. It involves a gradual decline over time, resulting from a complex interplay of processes that cause cellular damage.

The accumulation of cellular waste, genetic errors, and imperfect repairs are among the factors contributing to ageing.

9 Key Markers (Hallmarks) of Ageing

Scientists have identified nine key markers of aging, referred to as hallmarks, which provide valuable insights into the aging process. Understanding these hallmarks enables us to collaborate on optimising the aging journey together.

Learn more about each of these key markers of ageing below

Impacts of Hallmarks of Ageing

To truly grasp the intricacies of the hallmarks of ageing, imagine them as everyday experiences we all encounter as we grow older. These tangible examples offer a relatable lens, making the science of ageing more personal and understandable. Dive in and see how these hallmarks might be showing up in your own life
Genomic Instability

Genomic Instability

Ever noticed more frequent illnesses or unusual skin spots? Damaged DNA can increase the risk of diseases like cancer.
Telomere attrition

Telomere attrition

Feeling like you're aging faster than your peers? Shortened telomeres might be accelerating your cellular aging.
Epigenetic alterations

Epigenetic alterations

Ever wonder why you develop new allergies or sensitivities? Changes in gene patterns can lead to unexpected reactions.
Loss of proteostasis

Loss of proteostasis

Experiencing muscle weakness or memory issues? Faulty proteins might be affecting your muscle and brain functions.
Deregulated Nutrient Sensing

Deregulated Nutrient Sensing

Finding it harder to stay full or energized after meals? Your cells might not be using nutrients as efficiently.
Mitochondrial dysfunction

Mitochondrial dysfunction

Feeling constantly tired, even after a good night's sleep? Your cellular "batteries" might not be producing energy as they used to.
Cellular senescence

Cellular senescence

Experiencing more inflammation or slower healing? Inactive cells might be causing inflammation and delaying repair.
Altered intercellular communication

Altered intercellular communication

Feeling out of sync or more susceptible to illnesses? Poor cell communication might be affecting your body's defenses.
Stem cell exhaustion

Stem cell exhaustion

Noticed scars lasting longer or thinning hair? Reduced stem cells might be slowing your body's repair and renewal.

The nine markers of ageing

Curious about the science behind these everyday aging signs? Let's delve deeper and uncover the fascinating details of each hallmark. It's a journey from the familiar to the foundational
Genomic Instability

As we age, our DNA may sustain damage or mutations, leading to genetic instability and an increased risk of diseases like cancer.

 Telomere Attrition

Telomeres, protective caps at the end of the chromosomes, shorten over time. Shortened telomeres are linked to cellular ageing and a higher susceptibility to age related ailments.

Epigenetic alterations

Changes in gene expression patterns occur with aging, contributing to the development of age-related diseases

 Loss of Proteostasis

Aging can affect the body's ability to maintain proper protein function, leading to the accumulation of damaged or misfolded proteins and an elevated risk of age-related diseases

 Deregulated Nutrient Sensing

Dysregulated nutrient-level-regulated pathways disrupt our cells' ability to respond to nutrient signals, affecting energy production

 Mitochondrial dysfunction

Mitochondria, the energy-producing organelles in our cells, experience declining function with age, leading to decreased energy production and an increased risk of age-related diseases

 Cellular senescence

Senescent cells, which cease to divide, can accumulate with age, promoting inflammation and contributing to age-related diseases

 Stem Cell Exhaustion

The number and function of stem cells, responsible for tissue repair and regeneration, can decline with age, impacting the body's ability to regenerate tissues

 Altered Intercellular Communication

With age,communication between cells can become disrupted, affecting tissue function and increasing the risk of age-related diseases
Genomic Instability
Telomere Attrition
Epigenetic alterations
Loss of Proteostasis
Deregulated Nutrient Sensing
Mitochondrial dysfunction
Cellular senescence
Stem Cell Exhaustion
Altered Intercellular Communication

Unlocking the Science of Healthy Aging: The Power of Targeted Supplementation

Through rapid advances in Science, we understand that supplementation with certain nutrients and compounds has been shown to help mitigate some of these markers of aging.

For example, antioxidants like vitamins C and E provide vital protection against genomic instability and oxidative damage, fortifying your cellular health.

NAD+ precursors, such as nicotinamide riboside, play a pivotal role in supercharging healthy mitochondrial function and cellular metabolism.

Compounds like resveratrol and fisetin exhibit potent anti-inflammatory and anti-senescence effects, bolstering your cells in maintaining essential function.

At Numerus Biology, we harness the power of these science-backed nutrients and compounds to develop supplements that drive results in healthy aging and vitality.

Our products, led by the groundbreaking NB1™, incorporate these cutting-edge advancements to amplify your aging journey. By complementing a balanced diet and lifestyle, our supplements provide the robust support needed to promote healthy aging and unlock your peak potential at any age.

References:

1.López-Otín, C.,Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.

2.Ziegler, D. V., & Wiley, C. D. (2017). Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging cell, 16(3), 434-446.

3.Stein, L. R., & Imai, S. (2012). The dynamic regulation of NAD metabolism in mitochondria. Trends in endocrinology & metabolism, 23(9), 420-428.

Unlock more insights on the hallmarks of ageing and how to navigate them.